Description

Pentafluoropropionyl Chloride is a highly reactive fluorinated acyl chloride derivative, serving as a critical building block for introducing the pentafluoropropionyl group into target molecules. Its primary value lies in enabling the synthesis of advanced materials and active pharmaceutical ingredients (APIs) with enhanced stability and specific performance characteristics. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for applications requiring precise fluorination.

Application

• Pharmaceutical Intermediates: Key reagent in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and diagnostic agents.
• Agrochemical Synthesis: Used to create advanced fluorinated pesticides and herbicides with improved efficacy and environmental profiles.
• Derivatization Agent: Employed in analytical chemistry, particularly in Gas Chromatography (GC) and Mass Spectrometry (MS), for the derivatization of compounds to improve volatility and detection.
• Polymer & Material Science: Building block for synthesizing fluorinated monomers, polymers, and surface modifiers to impart oil, water, and chemical resistance.
• Liquid Crystal & Electronic Chemicals: Intermediate in the production of fluorinated compounds for electronic applications and display technologies.
• Custom Synthesis & Contract Manufacturing: A versatile reagent for custom fluorination and acylation reactions in fine chemical production.

Basic Information

Product Name	Pentafluoropropionyl Chloride
CAS No.	422-59-3
Molecular Formula	C3ClF5O
Molecular Weight	182.48 g/mol
Synonyms	Perfluoropropionyl Chloride; Pentafluoropropanoic Acid Chloride; 2,2,3,3,3-Pentafluoropropanoyl Chloride; Heptafluoropropionyl Chloride (common misnomer); PFP-Cl; C2F5C(O)Cl; Pentafluoropropionic Acid Chloride
EINECS	207-016-3

Quality Control

Our Pentafluoropropionyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.