Description

4,4,4-Trifluorocrotonoyl Chloride is a versatile fluorinated acid chloride building block essential for advanced organic synthesis. This compound is valued for its ability to introduce the reactive trifluorocrotonoyl moiety, enabling the creation of complex molecules with enhanced properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, imparting valuable properties like oil/water repellency, chemical resistance, and low surface energy.
• Organic Synthesis Reagent: A versatile reagent for acylation and condensation reactions in academic and industrial R&D laboratories.
• Fluorinated Surfactant Precursor: Used in the synthesis of specialty surfactants and surface-active agents with unique performance characteristics.

Basic Information

Product Name	4,4,4-Trifluorocrotonoyl Chloride
CAS No.	406-92-8
Molecular Formula	C4H2ClF3O
Molecular Weight	158.51 g/mol
Synonyms	4,4,4-Trifluorobut-2-enoyl chloride; (E)-4,4,4-Trifluorocrotonoyl chloride; 4,4,4-Trifluoro-2-butenoyl chloride; 2-Butenoyl chloride, 4,4,4-trifluoro-; Crotonoyl chloride, 4,4,4-trifluoro-; 4,4,4-Trifluorocrotonyl chloride; TFCC; 406-92-8
EINECS	206-983-5

Quality Control

Our 4,4,4-Trifluorocrotonoyl Chloride is manufactured under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP requirements for pharmaceutical applications and can provide regulatory documentation as needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.