Description

4,4,4-Trifluorobutanoyl Chloride is a versatile fluorinated acid chloride building block essential for introducing the trifluoropropyl moiety into complex molecules. Its high reactivity makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) with tailored properties. This compound is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoropropyl group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atoms contribute to increased efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to influence molecular polarity and packing.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, enhancing properties such as chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis Reagent: A fundamental reagent for Friedel-Crafts acylation, esterification, and amidation reactions in research and fine chemical production.
• Fluorinated Surfactant Precursor: Used in the manufacture of specialty surfactants and surface-active agents with unique wetting and spreading properties.

Basic Information

Product Name	4,4,4-Trifluorobutanoyl Chloride
CAS No.	406-91-7
Molecular Formula	C4H4ClF3O
Molecular Weight	160.52 g/mol
Synonyms	4,4,4-Trifluorobutyryl Chloride; Butanoyl Chloride, 4,4,4-trifluoro-; 4,4,4-Trifluorobutanoic Acid Chloride; 4,4,4-Trifluorobutyric Acid Chloride; γ,γ,γ-Trifluorobutyryl Chloride; TFBC; NSC 9235; 4,4,4-Trifluoro-1-oxobutyl Chloride
EINECS	206-983-8

Quality Control

Our 4,4,4-Trifluorobutanoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to maximize stability. Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Acidity (Titration)	≤ 1.0% (as HCl)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.