Description

(4-Fluorophenoxy)Acetyl Chloride CAS NO 405-78-7 is a high-purity, reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the (4-fluorophenoxy)acetyl moiety, a key structural motif in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable and high-quality source for complex molecule assembly.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorophenoxy group enhances biological activity and stability.
• Peptide Mimetics & Modifications: Employed in the acylation of amino groups to create modified peptides and peptide-like structures for biochemical research.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Chemistry: Acts as a monomer or modifying agent in the synthesis of specialty polymers with tailored properties.
• Material Science Research: Utilized in surface functionalization and the creation of advanced organic materials for electronic or optical applications.

Basic Information

Product Name	(4-Fluorophenoxy)Acetyl Chloride
CAS No.	405-78-7
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	2-(4-Fluorophenoxy)acetyl chloride; 4-Fluorophenoxyacetyl chloride; (p-Fluorophenoxy)acetyl chloride; Acetyl chloride, (4-fluorophenoxy)-; 4-Fluorophenoxyacetic acid chloride; NSC 403796; 2-(4-Fluorophenoxy)ethanoyl chloride
EINECS	Contact for details

Quality Control

Our (4-Fluorophenoxy)Acetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture. Store away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.