Description

Difluoroacetic Anhydride is a highly reactive fluorinated organic reagent. This compound is essential for introducing the difluoroacetyl group into target molecules, a key step in the synthesis of advanced pharmaceutical intermediates and agrochemicals. It is primarily used by R&D chemists and process engineers in the fine chemical, pharmaceutical, and agrochemical industries for building complex, fluorine-containing molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the production of active pharmaceutical ingredients (APIs) containing difluoromethyl or difluoroacetyl motifs.
• Agrochemical Manufacturing: Used in the synthesis of novel herbicides, fungicides, and insecticides where fluorine substitution enhances biological activity and stability.
• Material Science Precursor: Serves as a monomer or modifying agent in the development of specialty polymers and fluorinated surface coatings.
• Organic Synthesis Reagent: Employed in acetylation and esterification reactions under controlled conditions to synthesize esters, amides, and other derivatives.
• Ligand and Catalyst Development: Used in research for modifying ligands or creating novel organometallic catalysts.
• Fluorine Chemistry Research: A fundamental reagent in academic and industrial laboratories exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	Difluoroacetic Anhydride
CAS No.	401-67-2
Molecular Formula	C4H2F4O3
Molecular Weight	174.05 g/mol
Synonyms	Acetic Acid, 2,2-Difluoro-, Anhydride; 2,2-Difluoroacetic Anhydride; Difluoroacetic Acid Anhydride; Bis(2,2-difluoroacetyl) Ether; DFAA; 2,2-Difluoroacetyl Anhydride
EINECS	206-935-1

Quality Control

Our Difluoroacetic Anhydride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic and reactive nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) and handle in a moisture-controlled environment. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.