Description

3-Nitro-4-Fluorobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of its nitro and fluorine substituents, which enable precise functionalization for creating complex molecules with targeted properties. This intermediate is essential for research and production in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated benzoyl moiety.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and pesticides, where the nitro and fluorine groups contribute to biological activity and stability.
• Liquid Crystal & Polymer Chemistry: Acts as a monomer or modifying agent for producing specialty polymers and liquid crystal materials with specific electronic or optical properties.
• Dyestuff & Pigment Production: Employed in the synthesis of complex organic dyes and pigments, leveraging its reactivity to form azo and other chromophoric structures.
• Cross-Coupling Reactions: Serves as an electrophile in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to construct biaryl systems.
• Peptide & Protein Research: Can be used as an acylating agent for modifying amino acids or peptides in biochemical research.

Basic Information

Product Name	3-Nitro-4-Fluorobenzoyl Chloride
CAS No.	400-94-2
Molecular Formula	C7H3ClFNO3
Molecular Weight	203.56 g/mol
Synonyms	4-Fluoro-3-nitrobenzoyl chloride; 3-Nitro-4-fluorobenzoic acid chloride; 4-Fluor-3-nitro-benzoylchlorid; Benzoic acid, 4-fluoro-3-nitro-, chloride; 3-Nitro-p-fluorobenzoyl chloride; p-Fluoro-m-nitrobenzoyl chloride; 3-Nitro-4-fluorobenzoylchloride
EINECS	Contact for details

Quality Control

Our 3-Nitro-4-Fluorobenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.