Description

1-[(2R,4S,5S)-4-Azido-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methyl-Pyrimidine-2,4-Dione is a high-purity nucleoside analog derivative, a critical building block in advanced pharmaceutical research and development. This compound is essential for the synthesis of modified oligonucleotides and probes, enabling breakthroughs in areas like antisense therapy and diagnostic assay development. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers specializing in nucleotide chemistry and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Antisense Oligonucleotide Synthesis: Used to incorporate modified bases into oligonucleotides for therapeutic and research applications.
• Probe Development: Serves as a building block for labeled nucleotides used in diagnostic assays and genomic research.
• Bioconjugation & Click Chemistry: The azido functional group enables efficient conjugation to alkyne-modified molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new bioactive molecules.
• Biochemical Tool Development: Integral for creating specialized reagents used in molecular biology and enzymology studies.

Basic Information

Product Name	1-[(2R,4S,5S)-4-Azido-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methyl-Pyrimidine-2,4-Dione
CAS No.	399024-19-2
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	4-Azido-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl azide (stereoisomer); 5-Methyl-2'-deoxyuridine-4'-azide; 4'-Azido-5-methyl-2'-deoxyuridine; 1-[(2R,4S,5S)-4-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; Azidothymidine precursor; Nucleoside azide derivative; Modified thymidine analog
EINECS	Contact for details

Quality Control

Our 1-[(2R,4S,5S)-4-Azido-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methyl-Pyrimidine-2,4-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. All batches are characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture absorption. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.