Description

5'-Dmtr-2'-Methseleno-Uridine is a high-purity, chemically modified nucleoside building block used in oligonucleotide synthesis. This compound is critical for the site-specific introduction of selenium functionality into nucleic acid strands, enabling advanced structural and functional studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic probes, and for fundamental research in structural biology and nucleic acid chemistry.

Application

• Oligonucleotide Synthesis: As a phosphoramidite precursor for the solid-phase synthesis of selenium-modified DNA and RNA strands.
• Structural Biology: Facilitating phase determination in X-ray crystallography of nucleic acids and protein-nucleic acid complexes via the anomalous scattering of selenium atoms.
• Therapeutic Development: Research and development of novel antisense oligonucleotides, aptamers, and siRNA with enhanced properties.
• Biophysical Studies: Probing nucleic acid structure, folding, and dynamics using selenium as a spectroscopic or chemical probe.
• Diagnostic Probe Design: Creating specialized probes for detection and analysis with unique chemical handles.
• Academic Research: Fundamental studies in chemical biology, medicinal chemistry, and nucleic acid technology.

Basic Information

Product Name	5'-Dmtr-2'-Methseleno-Uridine
CAS No.	393802-82-9
Molecular Formula	C27H30N2O8Se
Molecular Weight	589.50 g/mol
Synonyms	2'-Methylseleno-5'-O-(4,4'-dimethoxytrityl)uridine; 2'-Se-Methyl-5'-O-DMTr-uridine; 5'-O-(4,4'-Dimethoxytrityl)-2'-methylselenouridine; 2'-(Methylseleno)-5'-O-DMTr-uridine; Uridine, 2'-(methylseleno)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-; DMTr-2'-SeMe-U; 393802-82-9
EINECS	Contact for details

Quality Control

Our 5'-Dmtr-2'-Methseleno-Uridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider storage at -20°C under desiccant.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in common anhydrous organic solvents (e.g., acetonitrile, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.