Description

Lapatinib Ditosylate CAS NO 388082-77-7 is a high-potency, small-molecule tyrosine kinase inhibitor primarily used in pharmaceutical research and development. This compound matters as a critical active pharmaceutical ingredient (API) for targeting specific cancer pathways, offering significant value in the development of targeted oncology therapies. It is essential for pharmaceutical manufacturers, research institutions, and biotechnology companies engaged in the synthesis of innovative cancer treatments and preclinical studies.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the formulation of targeted anti-cancer medications.
• Oncology Research: A key reference standard and tool compound for studying EGFR and HER2/neu (ErbB-2) tyrosine kinase inhibition in cellular and biochemical assays.
• Preclinical Development: Utilized in pharmacokinetic, pharmacodynamic, and toxicology studies to support Investigational New Drug (IND) applications.
• Analytical Standard: Serves as a high-purity standard for quality control and method validation in analytical laboratories (HPLC, LC-MS).
• Drug Discovery: Used in structure-activity relationship (SAR) studies and as a lead compound for developing next-generation kinase inhibitors.
• Academic Research: Employed in university and institutional labs for fundamental research on signal transduction and cancer biology.

Basic Information

Product Name	Lapatinib Ditosylate
CAS No.	388082-77-7
Molecular Formula	C₃₃H₃₄ClFN₄O₄S • 2C₇H₆O₃S
Molecular Weight	925.46 g/mol
Synonyms	Lapatinib ditosylate salt; GW572016 ditosylate; N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine ditosylate; Tykerb ditosylate; Tyverb ditosylate; Lapatinib bis(p-toluenesulfonate); Lapatinib ditoluene sulfonate
EINECS	Contact for details

Quality Control

Our Lapatinib Ditosylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) with detailed chromatograms and full traceability are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and potency. Avoid repeated or prolonged exposure to air.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.