Description

2-Furancarboxaldehyde,5-[4-[[3-Chloro-4-[(3-Fluorophenyl)Methoxy]Phenyl]Amino]-6-Quinazolinyl]-, Mono(4-Methylbenzenesulfonate) CAS NO 388082-75-5 is a high-purity, non-salt form pharmaceutical intermediate and research chemical, specifically a mono tosylate salt derivative of a complex quinazoline-furan hybrid structure. This compound is of significant value for its role as a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and academic institutions engaged in advanced medicinal chemistry and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: Critical precursor in the multi-step synthesis of novel small-molecule drug candidates, particularly kinase inhibitors.
• Oncology Research: Serves as a core scaffold for developing compounds targeting specific cancer-related signaling pathways.
• Medicinal Chemistry & Lead Optimization: Used in structure-activity relationship (SAR) studies to modify and improve the potency and selectivity of drug-like molecules.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Biochemical Assay Standards: Can be utilized as a reference standard or inhibitor in high-throughput screening and biochemical assays.
• Academic Research: Used in university laboratories for cutting-edge research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	2-Furancarboxaldehyde,5-[4-[[3-Chloro-4-[(3-Fluorophenyl)Methoxy]Phenyl]Amino]-6-Quinazolinyl]-, Mono(4-Methylbenzenesulfonate)
CAS No.	388082-75-5
Molecular Formula	C32H23ClFN3O5S
Molecular Weight	616.06 g/mol
Synonyms	5-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]quinazolin-6-yl]furan-2-carbaldehyde 4-methylbenzenesulfonate; Afatinib Impurity 17; Afatinib Tosylate Intermediate; BIBW 2992 Tosylate Intermediate; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Tosylate Related Compound; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide 4-Methylbenzenesulfonate Analog; Giotrif Intermediate; Gilotrif Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting critical parameters such as assay purity and impurity profiles. Our quality commitment supports compliance with ICH guidelines for impurities and meets the exacting standards required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.