Description

Tandutinib CAS NO 387867-13-2 is a potent and selective small molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3) and platelet-derived growth factor receptor (PDGFR). This compound is of significant value in oncology research for targeting specific signaling pathways implicated in the proliferation and survival of certain cancer cells. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in the development of novel targeted cancer therapies and preclinical studies.

Application

• Oncology Research: Used as a critical biochemical tool for studying FLT3 and PDGFR signaling pathways in various cancer models, including acute myeloid leukemia (AML).
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the preclinical development of novel tyrosine kinase inhibitors (TKIs).
• Mechanistic Studies: Employed to investigate the role of FLT3 and PDGFR in cell proliferation, differentiation, and apoptosis.
• Biochemical Assays: Utilized in high-throughput screening (HTS) and in vitro kinase assays to evaluate inhibitor potency and selectivity.
• Pharmacology Research: Applied in pharmacokinetic (PK) and pharmacodynamic (PD) studies to understand the compound's absorption, distribution, metabolism, and excretion (ADME) profile.

Basic Information

Product Name	Tandutinib
CAS No.	387867-13-2
Molecular Formula	C₂₇H₃₃N₇O₃
Molecular Weight	503.60 g/mol
Synonyms	MLN 518; CT53518; 1-[4-(4-Methylpiperazin-1-yl)phenyl]-3-[4-(3-pyridinyl)pyrimidin-2-yl]urea; N-(4-(4-Methylpiperazin-1-yl)phenyl)-N'-(4-(pyridin-3-yl)pyrimidin-2-yl)urea
EINECS	Contact for details

Quality Control

Our Tandutinib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.