Description

Bicyclo[2.2.1]Heptane-2-Methanol, 5-Isothiocyanato--α--Methyl-, (1R,2S,4R,5S)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block featuring a reactive isothiocyanate group. This compound is critical for the synthesis of complex molecules where precise spatial orientation and functional group compatibility are paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced medicinal chemistry, asymmetric synthesis, and the development of novel chemical probes and drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.
• Ligand Synthesis: Used to prepare sophisticated chiral ligands for asymmetric catalysis, enhancing the enantioselectivity of transition metal-catalyzed reactions.
• Bioconjugation & Probe Development: The reactive isothiocyanate group enables covalent attachment to amines in proteins, peptides, or other biomolecules, making it valuable for creating fluorescent probes, affinity labels, and antibody-drug conjugates (ADCs).
• Material Science Research: Employed in the synthesis of novel monomers for specialty polymers with unique structural and optical properties.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic synthesis and for scaling up complex synthetic routes in process chemistry.

Basic Information

Product Name	Bicyclo[2.2.1]Heptane-2-Methanol, 5-Isothiocyanato--α--Methyl-, (1R,2S,4R,5S)-Rel- (9Ci)
CAS No.	387816-43-5
Molecular Formula	C10H15NOS
Molecular Weight	197.30 g/mol
Synonyms	(1R,2S,4R,5S)-5-Isothiocyanato-2-methylbicyclo[2.2.1]heptane-2-methanol; rel-(1R,2S,4R,5S)-5-Isothiocyanato-2-methyl-2-norbornanemethanol; 2-Norbornanemethanol, 5-isothiocyanato-2-methyl-, (1R,2S,4R,5S)-rel-; Chiral Norbornane Isothiocyanate Derivative; Bicyclo[2.2.1]heptane Methanol Isothiocyanate
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity. Every lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, enantiomeric/excess, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, keeping the material at 2-8°C under an inert atmosphere is recommended to maintain stability and prevent degradation of the reactive isothiocyanate group.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.