Description

Thymidine 3',5'-Diphosphate Disodium Salt is a high-purity nucleotide derivative, essential as a critical building block and substrate in biochemical research and development. Its primary value lies in its role as a specific precursor or inhibitor in enzymatic studies, particularly those involving DNA polymerases, kinases, and other nucleic acid-metabolizing enzymes. This compound is vital for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors, where it is used in assay development, drug discovery, and the synthesis of novel therapeutic agents.

Application

• Enzymology Research: Used as a specific substrate or inhibitor for studying the kinetics and mechanisms of DNA polymerases, reverse transcriptases, and nucleotidyltransferases.
• Drug Discovery & Screening: Serves as a key component in high-throughput screening assays to identify potential antiviral or anticancer compounds that target nucleotide metabolism.
• Diagnostic Kit Development: Incorporated into enzymatic assay kits for the detection and quantification of specific enzymes or co-factors in clinical and research settings.
• Biochemical Synthesis: Acts as a precursor in the enzymatic or chemical synthesis of modified nucleotides, oligonucleotides, and other complex biomolecules.
• Cellular Signaling Studies: Investigated for its potential role in intracellular signaling pathways as a nucleotide derivative.
• Academic & Industrial R&D: Fundamental reagent for basic research in molecular biology, genetics, and biochemistry across global institutions.

Basic Information

Product Name	Thymidine 3',5'-Diphosphate Disodium Salt
CAS No.	386229-77-2
Molecular Formula	C10H13N2Na2O11P2
Molecular Weight	488.13 g/mol
Synonyms	3',5'-dTDP disodium salt; Thymidine-3',5'-diphosphate disodium; TDP disodium salt; Thymidine 3',5'-bisphosphate disodium salt; 2'-Deoxythymidine 3',5'-diphosphate disodium salt; pdTp disodium; 5'-TDP disodium; dTDP disodium
EINECS	Contact for details

Quality Control

Every batch of Thymidine 3',5'-Diphosphate Disodium Salt is manufactured and tested under strict quality management systems. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure it meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin (LAL)	< 10 EU/mg (if required)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.