Description

2'-C-Methyl 5'-Cytidylic Acid is a chemically modified nucleoside monophosphate, a key building block in advanced oligonucleotide synthesis. This compound is crucial for the development of therapeutic nucleic acids, offering enhanced stability and target specificity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and production of novel antiviral agents and antisense oligonucleotide therapies.

Application

• Antiviral Drug Development: As a critical intermediate in the synthesis of nucleoside analogs targeting RNA viruses, including Hepatitis C Virus (HCV).
• Antisense Oligonucleotide (ASO) Synthesis: Used to incorporate modified cytidine residues into oligonucleotides to improve nuclease resistance and binding affinity.
• siRNA and miRNA Research: Serves as a modified nucleotide component in small interfering RNA (siRNA) and microRNA (miRNA) constructs for gene silencing studies.
• Medicinal Chemistry & Lead Optimization: Employed in structure-activity relationship (SAR) studies to develop novel therapeutic candidates with improved pharmacokinetic profiles.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving polymerases and other nucleic acid-metabolizing enzymes.
• Diagnostic Probe Development: Incorporated into nucleic acid probes to enhance stability and specificity for diagnostic applications.

Basic Information

Product Name	2'-C-Methyl 5'-Cytidylic Acid
CAS No.	386213-38-3
Molecular Formula	C10H15N3O8P
Molecular Weight	336.22 g/mol
Synonyms	2'-C-Methylcytidine 5'-monophosphate; 2'-Methylcytidine 5'-phosphate; 2'-C-Methylcytidine 5'-phosphate; 2'-C-Methyl-5'-CMP; 2'-Methyl-CMP; 2'-C-Me-CMP; β-D-2'-C-Methylcytidine 5'-monophosphate; 2'-Methylcytidylic Acid
EINECS	Contact for details

Quality Control

Our 2'-C-Methyl 5'-Cytidylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.