Description

4-Piperidinecarbonyl Chloride, 1-(1-Methylethyl)- (9Ci) is a specialized organic building block featuring a reactive acid chloride functional group on a substituted piperidine scaffold. This compound matters for its critical role as a key intermediate in the synthesis of complex pharmaceutical molecules and advanced agrochemicals. It is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce the 1-isopropylpiperidine-4-carbonyl moiety into target structures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and cardiovascular drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require the piperidine pharmacophore.
• Chemical Research & Development: Serves as a versatile reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetic Chemistry: Employed to incorporate constrained, non-natural amino acid analogs into peptide chains to enhance stability and bioavailability.
• Ligand Synthesis for Catalysis: Used in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Acts as a precursor for the manufacture of other high-value, complex organic compounds used in various industrial applications.

Basic Information

Item	Details
Product Name	4-Piperidinecarbonyl Chloride, 1-(1-Methylethyl)- (9Ci)
CAS No.	385831-46-9
Molecular Formula	C9H16ClNO
Molecular Weight	189.68 g/mol
Synonyms	1-Isopropylpiperidine-4-carbonyl chloride; 1-(Propan-2-yl)piperidine-4-carbonyl chloride; 4-(Chlorocarbonyl)-1-isopropylpiperidine; 1-Isopropyl-4-piperidinecarbonyl chloride; NSC 405124; 385831-46-9; 1-(1-Methylethyl)-4-piperidinecarbonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Piperidinecarbonyl Chloride, 1-(1-Methylethyl)- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.