Description

6-Methyl-3-(β-D-2-Deoxy-Ribofuranosyl)Furano[2,3-D]Pyrimidin-2-One CAS NO 383897-60-7 is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel antiviral and anticancer agents, particularly in the development of modified nucleosides and oligonucleotides. It is essential for research institutions, pharmaceutical companies, and CROs engaged in drug discovery programs targeting viral infections and oncology.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Antiviral Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting DNA and RNA viruses.
• Oncology Drug Discovery: Serves as a building block for creating nucleotide analogs that interfere with cancer cell DNA replication and repair mechanisms.
• Oligonucleotide Synthesis: Employed in the preparation of modified oligonucleotides for antisense therapy, siRNA, and diagnostic probes.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and related pathways.
• Process Development: Acts as a reference standard and starting material for scaling up synthetic routes under cGMP conditions.

Basic Information

Product Name	6-Methyl-3-(β-D-2-Deoxy-Ribofuranosyl)Furano[2,3-D]Pyrimidin-2-One
CAS No.	383897-60-7
Molecular Formula	C₁₃H₁₆N₂O₅
Molecular Weight	280.28 g/mol
Synonyms	6-Methyl-3-(2-deoxy-β-D-ribofuranosyl)furo[2,3-d]pyrimidin-2(3H)-one; 6-Methyl-3-(2-deoxy-β-D-erythro-pentofuranosyl)furo[2,3-d]pyrimidin-2(3H)-one; 6-Methyl-3-(2-deoxy-β-D-ribofuranosyl)furano[2,3-d]pyrimidin-2-one; 2(3H)-Furo[2,3-d]pyrimidinone, 6-methyl-3-(2-deoxy-β-D-erythro-pentofuranosyl)-; Nucleoside analog intermediate; Modified deoxyribonucleoside
EINECS	Contact for details

Quality Control

Our 6-Methyl-3-(β-D-2-Deoxy-Ribofuranosyl)Furano[2,3-D]Pyrimidin-2-One is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development projects requiring material that aligns with ICH guidelines and cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.