Description

2-Methoxy-n-[(2E)-3-[4-[[3-Methyl-4-[(6-Methyl-3-Pyridinyl)Oxy]Phenyl]Amino]-6-Quinazolinyl]-2-Propen-1-Yl]Acetamide is a sophisticated quinazoline derivative, a key chemical scaffold in advanced pharmaceutical research and development. This compound is valued for its role as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis of targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers focused on oncology and kinase inhibitor development, where precise molecular structure is paramount for biological activity.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of novel kinase inhibitors and targeted cancer therapies.
• Biochemical Research: Used as a reference standard or probe compound in enzymatic assays and structure-activity relationship (SAR) studies.
• Preclinical Development: Employed in the formulation and testing of new chemical entities (NCEs) during drug discovery phases.
• Academic Research: Utilized in university and institutional labs for investigating quinazoline-based pharmacology and medicinal chemistry.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Item	Details
Product Name	2-Methoxy-n-[(2E)-3-[4-[[3-Methyl-4-[(6-Methyl-3-Pyridinyl)Oxy]Phenyl]Amino]-6-Quinazolinyl]-2-Propen-1-Yl]Acetamide
CAS No.	383432-38-0
Molecular Formula	C27H27N5O3
Molecular Weight	469.54 g/mol
Synonyms	N-[2E)-3-[4-[[3-Methyl-4-[(6-Methylpyridin-3-yl)oxy]phenyl]amino]quinazolin-6-yl]prop-2-en-1-yl]-2-methoxyacetamide; 383432-38-0; UNII-9J4865I39V; 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide; 9J4865I39V; AKOS025310991; BDBM50388835; ZINC000003869755
EINECS	Contact for details

Quality Control

Our 2-Methoxy-n-[(2E)-3-[4-[[3-Methyl-4-[(6-Methyl-3-Pyridinyl)Oxy]Phenyl]Amino]-6-Quinazolinyl]-2-Propen-1-Yl]Acetamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.