Description

4-Pyridinecarbonyl Chloride, 3,5-Difluoro- (9Ci) is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. Its core value lies in its reactive acid chloride group and strategically placed fluorine atoms, enabling precise molecular modifications. This compound is critically needed by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated pyridine-based active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used to construct advanced fluorinated pyridine cores for next-generation herbicides, fungicides, and insecticides, enhancing bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile building block for creating novel fluorinated ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials where the fluorinated pyridine moiety imparts specific electronic or physical properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes requiring high regiochemical purity and reliable reactivity.

Basic Information

Product Name	4-Pyridinecarbonyl Chloride, 3,5-Difluoro- (9Ci)
CAS No.	383363-42-6
Molecular Formula	C6H2ClF2NO
Molecular Weight	177.54 g/mol
Synonyms	3,5-Difluoropyridine-4-carbonyl chloride; 3,5-Difluoropyridine-4-carboxylic acid chloride; 3,5-Difluoropyridine-4-carbonyl chloride (9CI); 3,5-Difluoropyridine-4-carboxylic chloride; 4-Carbonyl chloride-3,5-difluoropyridine; 4-Pyridinecarbonyl chloride, 3,5-difluoro-; 3,5-Difluoroisonicotinoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Pyridinecarbonyl Chloride, 3,5-Difluoro- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.