Description

4-(2-Chloro-Benzyloxy)-3-Methoxy-Benzoyl Chloride is a high-purity, reactive benzoyl chloride derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce the 4-(2-chlorobenzyloxy)-3-methoxy-benzoyl moiety into target molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex benzamide or ester functionalities.
• Agrochemical Active Ingredient Precursor: Used in the manufacture of herbicides, fungicides, and plant growth regulators.
• Liquid Crystal & OLED Material Synthesis: Serves as a building block for advanced electronic materials requiring specific aromatic ester linkages.
• Polymer Modification Agent: Employed to introduce functional side chains into polymers to alter physical or chemical properties.
• Peptide Mimetics & Bioconjugation: Useful in medicinal chemistry for creating peptide analogs or for labeling biomolecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.
• Academic & Industrial Research: A valuable reagent for methodological development and exploring new chemical reactions in R&D laboratories.

Basic Information

Product Name	4-(2-Chloro-Benzyloxy)-3-Methoxy-Benzoyl Chloride
CAS No.	381205-83-0
Molecular Formula	C16H14Cl2O3
Molecular Weight	325.19 g/mol
Synonyms	3-Methoxy-4-[(2-chlorophenyl)methoxy]benzoyl chloride; 4-(2-Chlorobenzyloxy)-3-methoxybenzoic acid chloride; 2-Chloro-α-(3-methoxy-4-((2-chlorobenzyl)oxy)phenyl)benzeneacetyl chloride (related); Benzoic acid, 4-[(2-chlorophenyl)methoxy]-3-methoxy-, chloride; 4-[(2-Chlorobenzyl)oxy]-3-methoxybenzoyl chloride; 4-(2-Chloro-benzyloxy)-3-methoxy-benzoyl chloride; 381205-83-0 (CAS Index Name).
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-Benzyloxy)-3-Methoxy-Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.