Description

(2R)-1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-5-(Trimethylsilyl)-4-Pentyn-2-Ol is a high-value, chiral silyl-protected intermediate crucial for advanced organic synthesis. Its primary value lies in its dual-protected alkyne and alcohol functionalities, which enable precise stereochemical control in complex molecule construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, especially those requiring stereospecific alkyne incorporation.
• Asymmetric Synthesis: Used in stereoselective reactions to introduce protected hydroxyl and alkyne groups with high enantiomeric purity.
• Natural Product Synthesis: Facilitates the construction of challenging segments in natural products containing acetylene and alcohol moieties.
• Peptidomimetics & Bioconjugation: Serves as a precursor for introducing "click chemistry" handles (via the alkyne) into peptides and biomolecules.
• Material Science Research: Employed in the development of novel organic materials and polymers where controlled functional group presentation is critical.
• Process Chemistry Development: Used for scaling up synthetic routes in pilot plants and commercial manufacturing under GMP-like conditions.

Basic Information

Product Name	(2R)-1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-5-(Trimethylsilyl)-4-Pentyn-2-Ol
CAS No.	380909-90-0
Molecular Formula	C14H30O2Si2
Molecular Weight	286.56 g/mol
Synonyms	(2R)-1-[(tert-Butyldimethylsilyl)oxy]-5-(trimethylsilyl)-4-pentyn-2-ol; (R)-1-((tert-Butyldimethylsilyl)oxy)-5-(trimethylsilyl)pent-4-yn-2-ol; TBDMS-protected (R)-pentynol silyl ether; (2R)-1-(TBDMS-oxy)-5-(TMS)-4-pentyn-2-ol; (R)-TBDMS-O-CH2-CH(OH)-CH2-C≡C-TMS; CAS 380909-90-0; tert-Butyldimethyl((R)-4-hydroxy-1-trimethylsilyl-1-butyn-1-yloxy)silane
EINECS	Contact for details

Quality Control

Our (2R)-1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-5-(Trimethylsilyl)-4-Pentyn-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.