Description

Rac-5-(4-Fluorophenyl)-2-Methyl-1,3-Thiazole-4-Carbonyl Chloride is a versatile and high-purity organic intermediate, specifically an acid chloride derivative of a fluorinated thiazole. This compound is a critical building block in modern synthetic chemistry, enabling the efficient introduction of a complex heterocyclic moiety into target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and advanced materials. Its well-defined structure and reactivity make it an essential reagent for medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting neurological disorders, inflammation, and metabolic diseases.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Peptide Mimetic Synthesis: Serves as a coupling agent or core scaffold for creating peptidomimetics and other bioactive molecules.
• Agrochemical Development: Employed in the research and synthesis of novel herbicides, fungicides, and insecticides.
• Material Science: Can be incorporated into polymers or liquid crystals to impart specific electronic or structural properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and scale-up services.

Basic Information

Product Name	Rac-5-(4-Fluorophenyl)-2-Methyl-1,3-Thiazole-4-Carbonyl Chloride
CAS No.	380899-53-6
Molecular Formula	C11H7ClFNOS
Molecular Weight	255.70 g/mol
Synonyms	5-(4-Fluorophenyl)-2-methyl-1,3-thiazole-4-carbonyl chloride; 4-Fluorophenyl-2-methylthiazole-4-carbonyl chloride; 2-Methyl-5-(4-fluorophenyl)-4-thiazolecarbonyl chloride; (±)-5-(4-Fluorophenyl)-2-methyl-4-thiazolecarbonyl chloride; 4-Thiazolecarbonyl chloride, 5-(4-fluorophenyl)-2-methyl-; rac-5-(p-Fluorophenyl)-2-methylthiazole-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Our Rac-5-(4-Fluorophenyl)-2-Methyl-1,3-Thiazole-4-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.