Description

Phenyl Hydrogen ((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphonate is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is critical for the research and development of novel antiviral and anticancer therapeutics, particularly those targeting nucleotide metabolism pathways. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and CDMOs engaged in the synthesis of modified nucleoside analogs and prodrugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral prodrugs, particularly for hepatitis B (HBV) and other viral infections.
• Anticancer Drug Research: Used in the development of nucleotide analogs that target DNA/RNA synthesis in cancer cells.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide kinases and polymerases.
• Prodrug Development: The phosphonate moiety is instrumental in creating orally bioavailable prodrug forms of active nucleotide metabolites.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	Phenyl Hydrogen ((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphonate
CAS No.	379270-35-6
Molecular Formula	C15H18N5O4P
Molecular Weight	363.31 g/mol
Synonyms	((((R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid phenyl ester; (R)-Phenyl (((1-(6-Aminopurin-9-yl)propan-2-yl)oxy)methyl)phosphonate; 9-[(1R)-2-[[(Phenoxyphosphinyl)methoxy]methyl]ethyl]adenine; Adefovir Phenyl Ester Intermediate; GS-7340 Phenyl Ester Intermediate; Tenofovir Alafenamide (TAF) Related Compound; Phosphonate Prodrug Intermediate
EINECS	Contact for details

Quality Control

Our Phenyl Hydrogen ((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphonate is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and enantiomeric excess, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting regulatory filings and GMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.