Description

Saracatinib (AZD0530) is a potent, orally bioavailable, and highly selective dual Src/Abl tyrosine kinase inhibitor. This compound is a critical research tool and pharmaceutical intermediate for developing targeted cancer therapies. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and contract manufacturing organizations (CMOs) focused on oncology drug discovery and development.

Application

• Oncology Research & Drug Discovery: A key reference standard and active pharmaceutical ingredient (API) intermediate in the development of Src and Abl kinase-targeted therapeutics.
• Biochemical Assay Development: Used as a selective inhibitor to study Src and Abl kinase signaling pathways in cellular and enzymatic assays.
• Preclinical Studies: Employed in in vitro and in vivo models to investigate mechanisms of tumor progression, metastasis, and potential therapeutic efficacy.
• Pharmaceutical Synthesis: Serves as a high-purity building block for the cGMP-compliant synthesis of investigational new drugs (INDs) and clinical trial materials.
• Mechanism of Action (MoA) Studies: Essential for validating drug targets and understanding resistance mechanisms in various cancer cell lines.

Basic Information

Product Name	Saracatinib
CAS No.	379231-04-6
Molecular Formula	C₂₃H₂₂ClFN₄O₃
Molecular Weight	456.90 g/mol
Synonyms	AZD0530; Saracatinib (AZD0530); 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; 6-Methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-4-[(2,4-dichloro-5-methoxyphenyl)amino]-3-quinolinecarbonitrile; SRC/ABL Inhibitor (AZD0530); UNII-4CQ5P7U6TI
EINECS	Contact for details

Quality Control

Our Saracatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. Certificates of Analysis (COA) with full traceability are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm
Assay (HPLC)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.