Description

3-(4-Chloro-2-Fluoro-Phenyl)-Propan-1-Ol CAS NO 377083-99-3 is a versatile fluorinated aromatic alcohol intermediate of significant importance in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the phenyl ring, makes it a valuable building block for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries. It serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and specialized crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens used in high-performance display technologies.
• Organic Electronics: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials.
• Chemical Research: A valuable reagent for academic and industrial research into new fluorination reactions and cross-coupling methodologies.
• Fine Chemical Production: Used in the multi-step synthesis of complex fragrance and dye molecules requiring specific halogenated intermediates.

Basic Information

Item	Details
Product Name	3-(4-Chloro-2-Fluoro-Phenyl)-Propan-1-Ol
CAS No.	377083-99-3
Molecular Formula	C9H10ClFO
Molecular Weight	188.63 g/mol
Synonyms	3-(4-Chloro-2-fluorophenyl)propan-1-ol; 4-Chloro-2-fluoro-β-hydroxypropylbenzene; 1-(4-Chloro-2-fluorophenyl)-3-propanol; (3-(4-Chloro-2-fluorophenyl)propyl) alcohol; 377083-99-3; 4-Chloro-2-fluorohydrocinnamyl alcohol; 3-(4-Chloro-2-fluorophenyl)propyl alcohol
EINECS	Contact for details

Quality Control

Every batch of 3-(4-Chloro-2-Fluoro-Phenyl)-Propan-1-Ol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support cGMP and ISO guidelines for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.