Description

Cyclohexanecarbonyl Chloride, 4,4-Difluoro- (9Ci) is a high-value fluorinated building block used in advanced organic synthesis. This compound is critical for introducing the 4,4-difluorocyclohexanecarbonyl moiety, a key structural motif in modern pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the life sciences sector for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluorocyclohexyl group can enhance bioavailability and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with unique surface properties and chemical resistance.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global pharmaceutical pipeline.

Basic Information

Product Name	Cyclohexanecarbonyl Chloride, 4,4-Difluoro- (9Ci)
CAS No.	376348-75-3
Molecular Formula	C7H9ClF2O
Molecular Weight	182.60 g/mol
Synonyms	4,4-Difluorocyclohexanecarbonyl chloride; 4,4-Difluorocyclohexanoyl chloride; 4,4-Difluorocyclohexanecarboxylic acid chloride; 4,4-Difluorocyclohexylcarbonyl chloride; 4,4-Difluorocyclohexanecarboxyl chloride; 4,4-Difluorocyclohexanecarboxylic chloride; 4,4-Difluorocyclohexanoylchloride
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Chloride, 4,4-Difluoro- (9Ci) is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.