Description

(R)-2,2,2-Trifluoro-1-(3-Chlorophenyl)Ethanol is a high-value chiral building block and intermediate of significant importance in modern synthetic chemistry. Its core value lies in its trifluoromethyl and chlorophenyl groups, which are crucial for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Material Science: Employed in the synthesis of specialty polymers and liquid crystals, where its specific stereochemistry and fluorine content impart unique properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high enantiomeric purity.

Basic Information

Product Name	(R)-2,2,2-Trifluoro-1-(3-Chlorophenyl)Ethanol
CAS No.	376347-10-3
Molecular Formula	C8H6ClF3O
Molecular Weight	210.58 g/mol
Synonyms	(R)-1-(3-Chlorophenyl)-2,2,2-trifluoroethanol; (R)-α-(Trifluoromethyl)-3-chlorobenzeneethanol; (R)-3-Chloro-α-(trifluoromethyl)benzyl alcohol; (R)-2,2,2-Trifluoro-1-(3-chlorophenyl)ethan-1-ol; (R)-TFM-CPEOH; (R)-Trifluoromethyl(3-chlorophenyl)carbinol; (R)-1-(3-Chlorophenyl)-2,2,2-trifluoroethyl alcohol
EINECS	Contact for details

Quality Control

Our (R)-2,2,2-Trifluoro-1-(3-Chlorophenyl)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure compliance with exacting customer specifications and industry standards. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.