Description

2'-C-Methylguanosine is a chemically modified nucleoside analog of guanosine, featuring a methyl group at the 2'-carbon position of the ribose sugar. This structural modification is critical for imparting unique biochemical properties, making it a valuable intermediate in pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel antiviral and anticancer therapeutics. The compound's role in probing RNA function and as a building block for modified oligonucleotides underscores its importance in advanced life science applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand RNA polymerase mechanisms and viral replication.
• Proteomics & Genomics: Essential component in the development of modified oligonucleotides for diagnostic assays and gene silencing research (e.g., siRNA, antisense oligonucleotides).
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2'-C-Methylguanosine
CAS No.	374750-30-8
Molecular Formula	C11H15N5O5
Molecular Weight	297.27 g/mol
Synonyms	2'-C-Methylguanosine; 2'-Methylguanosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-methyloxolan-2-yl]-1,9-dihydro-6H-purin-6-one; Guanosine, 2'-C-methyl-; 2'-Methyl-Guanosine; 2'-C-Me-Guo
EINECS	Contact for details

Quality Control

Our 2'-C-Methylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.