Description

9N-Trityl Guanine is a key nucleobase derivative, specifically a trityl-protected guanine analog, widely used as a critical building block in oligonucleotide synthesis. This high-purity intermediate is essential for researchers and manufacturers requiring precise control over nucleic acid structure and function. It is primarily utilized in the development of antisense oligonucleotides, primers, probes, and other advanced pharmaceutical and diagnostic applications.

Application

• Oligonucleotide Synthesis: Serves as a protected monomer in solid-phase and solution-phase synthesis of DNA and RNA strands.
• Antisense Drug Development: A crucial raw material for creating therapeutic oligonucleotides targeting specific genes.
• Diagnostic Probe Manufacture: Used in the production of labeled probes for PCR, sequencing, and microarray technologies.
• Research & Development: Employed in academic and industrial labs for studying nucleic acid chemistry, enzyme mechanisms, and gene function.
• Pharmaceutical Intermediates: Acts as a building block for novel nucleoside-based antiviral or anticancer agents.
• Bioconjugation: Facilitates the site-specific attachment of guanine derivatives to other molecules like peptides or fluorophores.

Basic Information

Product Name	9N-Trityl Guanine
CAS No.	374678-33-8
Molecular Formula	C24H19N5O
Molecular Weight	393.44 g/mol
Synonyms	9-(Triphenylmethyl)guanine; N9-Tritylguanine; Guanine, 9-(triphenylmethyl)-; 9-Trityl-9H-guanine; N-Trityl Guanine; Trt-Gua; 9-Triphenylmethylguanine; 9H-Guanine, 9-(triphenylmethyl)-
EINECS	Contact for details

Quality Control

Our 9N-Trityl Guanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical and research applications. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. A Certificate of Analysis (COA) is supplied with each batch to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.