Description

Benzenemethanol, 3-Fluoro-α-Methylene- (9Ci) is a specialized fluorinated benzyl alcohol derivative, serving as a high-value synthetic intermediate. Its core value lies in the strategic incorporation of both a fluorine atom and a reactive methylene group onto the aromatic ring, enabling precise molecular modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including potential kinase inhibitors and CNS-active molecules.
• Agrochemical Synthesis: Used in creating advanced, fluorinated pesticides and herbicides with enhanced biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions and as a ligand precursor in organometallic chemistry due to its functional handle.
• Fluorine-18 Radiochemistry: Potential precursor for the development of Positron Emission Tomography (PET) imaging tracers.
• Advanced Polymer Monomer: Can be utilized to introduce fluorinated benzyl groups into specialty polymers for unique surface properties.

Basic Information

Product Name	Benzenemethanol, 3-Fluoro-α-Methylene- (9Ci)
CAS No.	371157-33-4
Molecular Formula	C8H7FO
Molecular Weight	138.14 g/mol
Synonyms	3-Fluoro-α-methylenebenzenemethanol; (3-Fluorophenyl)(hydroxy)ethene; 3-Fluoro-α-methylene-benzyl alcohol; 1-(3-Fluorophenyl)ethen-1-ol; 3-Fluoro-α-methylenebenzyl alcohol; (3-Fluorobenzylidene)methanol; CAS 371157-33-4
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and purity for this advanced intermediate. Standard quality control includes identification by spectroscopic methods (IR, NMR), purity assessment by HPLC or GC, and control of key impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. Custom purity grades, including research and GMP standards, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0% (Research Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.