Description

4-Isoquinolinecarbonyl Chloride is a versatile and highly reactive acid chloride derivative of isoquinoline, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the efficient introduction of the isoquinolinecarbonyl moiety, a key structural motif in pharmaceuticals and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of drug candidates, particularly those targeting neurological disorders, cancer, and infectious diseases.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with the isoquinoline scaffold for enhanced efficacy.
• Material Science Research: Building block for developing organic semiconductors, ligands for catalysis, and specialty polymers.
• Peptide & Protein Modification: Acts as a coupling agent for introducing the isoquinoline group into peptides or biomolecules for biochemical studies.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for enzyme inhibition and cellular pathway analysis.
• Academic & Contract Research: Fundamental reagent for methodological development and novel compound library synthesis in R&D laboratories.

Basic Information

Product Name	4-Isoquinolinecarbonyl Chloride
CAS No.	370580-85-1
Molecular Formula	C10H6ClNO
Molecular Weight	191.62 g/mol
Synonyms	Isoquinoline-4-carbonyl chloride; 4-Carboxyisoquinoline chloride; 4-Isoquinolinecarboxylic acid chloride; 4-(Chlorocarbonyl)isoquinoline; 4-Isoquinoyl chloride; 370580-85-1; Isoquinoline-4-carbonylchloride
EINECS	Contact for details

Quality Control

Our 4-Isoquinolinecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.