Description

(2R,3R)-3-(2,5-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-Yl)Thiobutyramide is a high-purity, chiral chemical intermediate of significant importance in advanced pharmaceutical synthesis. Its precise stereochemistry and functional groups make it a critical building block for the development of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key precursor in the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of antifungal and other therapeutic agents.
• Agrochemical Synthesis: Used in the development of advanced crop protection products, particularly fungicides.
• Organic Synthesis Research: Serves as a valuable building block for constructing complex molecular architectures in medicinal chemistry.
• Biochemical Research: Employed in studies investigating enzyme inhibition and receptor-ligand interactions.
• Process Chemistry Development: Used for scaling up synthetic routes and optimizing manufacturing processes for target APIs.

Basic Information

Product Name	(2R,3R)-3-(2,5-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-Yl)Thiobutyramide
CAS No.	368421-58-3
Molecular Formula	C14H15F2N5O2S
Molecular Weight	355.37 g/mol
Synonyms	(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide; (2R,3R)-3-(2,5-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-Yl)Butanethioamide; 368421-58-3; (2R,3R)-3-(2,5-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-Yl)Thiobutyramide; (2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-methyl-4-(1,2,4-triazol-1-yl)butanethioamide
EINECS	Contact for details

Quality Control

Our (2R,3R)-3-(2,5-Difluorophenyl)-3-Hydroxy-2-Methyl-4-(1H-1,2,4-Triazol-1-Yl)Thiobutyramide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.