Description

Mubritinib is a potent and selective small-molecule inhibitor of the tyrosine kinase receptor HER2/ErbB2. This compound matters for researchers and developers as it provides a critical tool for investigating targeted cancer therapies and signal transduction pathways. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, particularly for studying breast cancer and other HER2-driven malignancies.

Application

• Oncology Research: A key investigational tool for studying HER2/ErbB2 signaling pathways and their role in tumorigenesis.
• Drug Discovery & Development: Used as a reference standard or lead compound in the development of novel tyrosine kinase inhibitors (TKIs).
• Biochemical Assays: Employed in in vitro enzymatic assays to determine inhibition kinetics and potency against HER2.
• Cellular Studies: Utilized in cell-based models to assess effects on proliferation, apoptosis, and downstream signaling in HER2-overexpressing cancer cell lines.
• Preclinical Research: Supports pharmacological and toxicological profiling in animal models of cancer.
• Mechanism of Action Studies: Helps elucidate the functional consequences of HER2 inhibition and potential resistance mechanisms.

Basic Information

Item	Detail
Product Name	Mubritinib
CAS No.	366017-09-6
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	TAK 165; TAK-165; Mubritinib (TAK-165); N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; UNII-5T6B4U6S4F; 5T6B4U6S4F
EINECS	Contact for details

Quality Control

Our Mubritinib is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets high-grade standards for research use. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.