Description

Benzene, 2-Chloro-4-Fluoro-1-Isothiocyanato- (9Ci) is a specialized aromatic building block featuring a reactive isothiocyanate group, making it a valuable intermediate for constructing complex molecular architectures. Its core value lies in enabling the synthesis of novel compounds for pharmaceutical and agrochemical research, where precise functionalization is critical. This high-purity intermediate is essential for R&D chemists and process development scientists in the life sciences and advanced materials sectors seeking to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, contributing to the development of next-generation crop protection solutions.
• Ligand and Probe Synthesis: Serves as a precursor for creating specialized chemical probes, ligands, and tags used in biochemical assays and diagnostic development.
• Material Science: Employed in the research and production of advanced polymers and functional materials requiring specific aromatic and thiourea linkages.
• Chemical Biology: Utilized for bioconjugation and protein labeling studies due to the reactivity of the isothiocyanate group with amines.
• Custom Synthesis: A fundamental building block for contract research and manufacturing organizations (CROs/CMOs) performing bespoke organic synthesis for clients.

Basic Information

Product Name	Benzene, 2-Chloro-4-Fluoro-1-Isothiocyanato- (9Ci)
CAS No.	362601-84-1
Molecular Formula	C7H3ClFNS
Molecular Weight	187.62 g/mol
Synonyms	2-Chloro-4-fluoro-1-isothiocyanatobenzene; 1-Chloro-3-fluoro-4-isothiocyanatobenzene; 2-Chloro-4-fluorophenyl isothiocyanate; 4-Fluoro-2-chlorophenyl isothiocyanate; (2-Chloro-4-fluorophenyl) isothiocyanate; Benzene, 2-chloro-4-fluoro-1-isothiocyanato-; 362601-84-1; 2-Cl-4-F-C6H3-NCS
EINECS	Contact for details

Quality Control

Our Benzene, 2-Chloro-4-Fluoro-1-Isothiocyanato- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to consistent quality and traceability supports your research and development needs with reliable, specification-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.