Description

6-(Trifluoromethyl)Nicotinoyl Chloride is a high-value, reactive chemical intermediate featuring a nicotinic acid core functionalized with a trifluoromethyl group and an acid chloride moiety. This compound matters for its role as a critical building block in modern synthetic chemistry, enabling the efficient introduction of the 6-(trifluoromethyl)nicotinoyl pharmacophore into target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, receptor modulators, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials requiring specific fluorine-containing aromatic units.
• Chemical Biology & Proteomics: Employed as a derivatization agent or linker for labeling biomolecules and studying protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical suppliers and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	6-(Trifluoromethyl)Nicotinoyl Chloride
CAS No.	358780-13-9
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	6-(Trifluoromethyl)nicotinoyl chloride; 6-(Trifluoromethyl)pyridine-3-carbonyl chloride; 3-Pyridinecarbonyl chloride, 6-(trifluoromethyl)-; Nicotinoyl chloride, 6-(trifluoromethyl)-; 6-Trifluoromethylnicotinoyl chloride; 6-Trifluoromethyl-3-pyridinecarbonyl chloride; 6-(Trifluoromethyl)-3-pyridinylcarbonyl chloride
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Nicotinoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.