Description

3-(3,5-Dimethylisoxazol-4-Yl)Propanoyl Chloride is a high-purity, reactive acid chloride derivative of a dimethylisoxazole moiety, serving as a critical building block in advanced organic synthesis. Its value lies in enabling the efficient introduction of the 3,5-dimethylisoxazole-4-propionyl functional group, a key structural motif in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, particularly in the development of enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting inflammatory and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the bioactivity of the isoxazole ring.
• Chemical Biology Probe Development: Employed to create covalent inhibitors or affinity labels for target identification and validation studies.
• Peptide & Protein Modification: Facilitates the acylation of amino groups to attach the lipophilic isoxazole-propionyl tag to biomolecules.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers with tailored properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for scale-up and production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	3-(3,5-Dimethylisoxazol-4-Yl)Propanoyl Chloride
CAS No.	358721-54-7
Molecular Formula	C9H10ClNO2
Molecular Weight	199.63 g/mol
Synonyms	4-(3-Chloro-3-oxopropyl)-3,5-dimethylisoxazole; 3,5-Dimethyl-4-(3-chloro-3-oxopropyl)isoxazole; 3-(3,5-Dimethyl-4-isoxazolyl)propanoyl chloride; 3,5-Dimethylisoxazole-4-propionyl chloride; 4-(2-Chlorocarbonylethyl)-3,5-dimethylisoxazole; Propanoyl chloride, 3-(3,5-dimethyl-4-isoxazolyl)-; 358721-54-7
EINECS	Contact for details

Quality Control

Our 3-(3,5-Dimethylisoxazol-4-Yl)Propanoyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) and separate from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.