Description

2-Amino-6-Iodo-2'-Deoxyguanosine is a modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and a versatile molecular probe for studying nucleic acid structure, function, and for the development of novel therapeutic agents. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in antiviral drug discovery, oligonucleotide synthesis, and molecular biology research.

Application

• Antiviral and Anticancer Nucleoside Analog Research: Serves as a precursor or intermediate in the synthesis of novel therapeutic agents targeting viral polymerases and cellular replication mechanisms.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite building block for incorporating specific functionalities or labels into synthetic DNA strands for probes and primers.
• Biochemical and Enzymatic Studies: Acts as a substrate or inhibitor to investigate the activity and specificity of enzymes like kinases, polymerases, and nucleoside transporters.
• Diagnostic Probe Development: Facilitates the creation of labeled nucleotides for use in detection assays, including fluorescence-based or radioactive tagging applications.
• Structural Biology: Employed in X-ray crystallography and NMR studies to understand nucleic acid interactions and ligand binding at the atomic level.
• Medicinal Chemistry & Lead Optimization: Provides a scaffold for structure-activity relationship (SAR) studies to enhance drug potency, selectivity, and metabolic stability.

Basic Information

Product Name	2-Amino-6-Iodo-2'-Deoxyguanosine
CAS No.	354823-77-1
Molecular Formula	C10H13IN6O3
Molecular Weight	392.15 g/mol
Synonyms	6-Iodo-2'-deoxyguanosine; 2-Amino-6-iodo-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-9-ium; 2'-Deoxy-6-iodoguanosine; 6-Iodo-2'-deoxyguanosine; 6-Iodo-dG; 2-Amino-6-iodo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one
EINECS	Contact for details

Quality Control

Our 2-Amino-6-Iodo-2'-Deoxyguanosine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. All materials are accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.