Description

Ethyl 4-(4-Fluorophenyl)-6-Phenyl-2-Thioxo-1,2,3,4-Tetrahydro-5-Pyrimidinecarboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and metabolic conditions.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) in academic and industrial R&D labs.
• Agrochemical Development: Used in research for creating novel pesticides or herbicides, leveraging its fluorinated phenyl and thiopyrimidine motifs.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme inhibition and biological pathway modulation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of client-specific target molecules.

Basic Information

Product Name	Ethyl 4-(4-Fluorophenyl)-6-Phenyl-2-Thioxo-1,2,3,4-Tetrahydro-5-Pyrimidinecarboxylate
CAS No.	353517-09-6
Molecular Formula	C19H17FN2O2S
Molecular Weight	356.41 g/mol
Synonyms	Ethyl 4-(4-fluorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate; 4-(4-Fluorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylic acid ethyl ester; 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(4-fluorophenyl)-6-phenyl-2-thioxo-, ethyl ester; CAS 353517-09-6; Fluorophenyl phenyl thiopyrimidine carboxylate; Dihydropyrimidine-2-thione derivative
EINECS	Contact for details

Quality Control

Our production of Ethyl 4-(4-Fluorophenyl)-6-Phenyl-2-Thioxo-1,2,3,4-Tetrahydro-5-Pyrimidinecarboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.