Description

4-Azido-2,3,5,6-Tetrafluorobenzamidocysteine Methanethiosulfonate is a specialized, high-purity chemical reagent designed for advanced bioconjugation and click chemistry applications. Its unique bifunctional structure, featuring an azido group and a methanethiosulfonate moiety, enables precise, site-specific labeling and cross-linking of biomolecules under mild conditions. This compound is essential for researchers and developers in pharmaceutical R&D, proteomics, and materials science who require reliable, high-performance tools for constructing complex molecular architectures.

Application

• Site-Specific Protein Labeling: Used to introduce azide handles onto cysteine residues for subsequent bioorthogonal conjugation with alkynes via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Bioconjugation Probe Synthesis: A key intermediate for creating fluorescent probes, affinity tags, and drug conjugates for targeted delivery and imaging studies.
• Surface Functionalization: Employed to modify gold surfaces, nanoparticles, and other materials with bioactive ligands for biosensor and diagnostic device development.
• Cross-linking Agent: Facilitates the study of protein-protein interactions and the stabilization of protein complexes through disulfide bridge formation.
• Chemical Biology Tool: Enables the exploration of enzyme mechanisms, protein folding, and structural dynamics through controlled chemical modification.
• Antibody-Drug Conjugate (ADC) Research: Serves as a linker precursor in the development of next-generation targeted cancer therapeutics.

Basic Information

Product Name	4-Azido-2,3,5,6-Tetrafluorobenzamidocysteine Methanethiosulfonate
CAS No.	352000-06-7
Molecular Formula	C11H7F4N5O4S2
Molecular Weight	397.33 g/mol
Synonyms	MTSSL Azide; S-(2,3,5,6-Tetrafluoro-4-azidobenzamido)cysteine Methanethiosulfonate; Azido-TFB-MTS; 4-Azido-tetrafluorobenzoyl-Cys-MTS; N-[(4-Azido-2,3,5,6-tetrafluorobenzoyl)-L-cysteinyl] methanesulfonothioate; ATFB-Cys-MTS; Azido-Pentafluorophenyl-Cysteine-MTS Derivative
EINECS	Contact for details

Quality Control

Every batch of 4-Azido-2,3,5,6-Tetrafluorobenzamidocysteine Methanethiosulfonate is manufactured and tested under strict quality management protocols to ensure consistency and purity for sensitive research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic analyses, to ensure compliance with exacting industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.