Description

tert-Butyl n-(6-Isothiocyanatohexyl)Carbamate is a specialized bifunctional organic compound featuring both a tert-butyloxycarbonyl (Boc) protected amine and a reactive isothiocyanate group. This molecular architecture makes it a valuable building block and linker molecule for the synthesis of complex chemical entities, particularly in advanced research and development. It is primarily utilized by pharmaceutical researchers, bioconjugation specialists, and material scientists who require precise and stable covalent attachment strategies.

Application

• Bioconjugation and Protein Labeling: The isothiocyanate group reacts with primary amines (e.g., lysine residues) to form stable thiourea linkages, enabling the attachment of fluorescent probes, drugs, or other functional molecules to proteins, antibodies, or peptides.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a versatile linker or side-chain protected intermediate for the controlled assembly of complex peptide sequences, where the Boc group provides orthogonal protection.
• Polymer and Material Science: Acts as a functional monomer or cross-linking agent for creating smart polymers, hydrogels, or surface-modified materials with tailored chemical properties.
• Small Molecule Drug Discovery: Used as a key intermediate in the synthesis of targeted drug candidates, especially those requiring a defined spacer arm between a pharmacophore and a targeting moiety.
• Diagnostic Reagent Development: Employed in the manufacture of reagents for immunoassays, biosensors, and other diagnostic platforms that rely on stable biomolecule conjugates.
• Chemical Biology Probes: Facilitates the creation of activity-based probes for studying enzyme function, protein-protein interactions, and cellular pathways.

Basic Information

Product Name	tert-Butyl n-(6-Isothiocyanatohexyl)Carbamate
CAS No.	347890-44-2
Molecular Formula	C₁₂H₂₂N₂O₂S
Molecular Weight	258.38 g/mol
Synonyms	Boc-6-aminohexyl isothiocyanate; 6-[(tert-Butoxycarbonyl)amino]hexyl isothiocyanate; N-Boc-1,6-diaminohexane isothiocyanate; N-(6-Isothiocyanatohexyl)carbamic acid tert-butyl ester; tert-Butyl (6-isothiocyanatohexyl)carbamate; Boc-NH-(CH2)6-NCS; 1,6-Hexanediamine, N-(1,1-dimethylethoxy)carbonyl-, N-isothiocyanato-
EINECS	Contact for details

Quality Control

Our production of tert-Butyl n-(6-Isothiocyanatohexyl)Carbamate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and IR spectroscopy, to confirm identity and purity. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, dichloromethane, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.