Description

6-Thioguanosine Hydrate is a modified nucleoside analog of guanosine, where the oxygen atom at the 6-position is replaced by sulfur. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a key intermediate and its potential biological activities. It is primarily utilized by researchers and manufacturers in the life sciences sector for applications in nucleotide chemistry, antiviral studies, and as a building block for oligonucleotide synthesis.

Application

• Biochemical Research: Used as a critical reagent and reference standard in studies of nucleic acid metabolism, enzyme mechanisms, and nucleoside transport.
• Pharmaceutical Intermediates: Serves as a key synthetic precursor in the development of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Acts as a modified building block for the solid-phase synthesis of oligonucleotides with specific properties for diagnostic or therapeutic applications.
• Antiviral Studies: Investigated for its potential activity and mechanism of action against various viral targets.
• Enzyme Inhibition Studies: Employed to study the inhibition of purine-metabolizing enzymes like purine nucleoside phosphorylase (PNP).
• Metabolic Pathway Analysis: Used as a tracer or inhibitor to elucidate pathways in purine salvage and nucleotide biosynthesis.

Basic Information

Product Name	6-Thioguanosine Hydrate
CAS No.	345909-25-3
Molecular Formula	C10H13N5O4S · xH2O
Molecular Weight	299.31 g/mol (Anhydrous basis)
Synonyms	6-Thioguanosine monohydrate; 2-Amino-6-mercapto-9-β-D-ribofuranosylpurine hydrate; 6-TG Hydrate; 6-Thio-Guanosine Hydrate; 6-SG Hydrate; 6-Mercaptoguanosine Hydrate; NSC 752 Hydrate; Thioguanine riboside Hydrate
EINECS	Contact for details

Quality Control

Our 6-Thioguanosine Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and LOD for water content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccation and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.