Description

4H-3,1-Benzoxazine-2-Carbonyl Chloride, 4-Oxo- (9Ci) is a high-value, reactive chemical intermediate belonging to the benzoxazine class, characterized by its carbonyl chloride functional group. This compound is critical for facilitating efficient synthetic transformations, particularly in the construction of complex heterocyclic scaffolds and active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel compounds and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those with benzoxazine or related heterocyclic cores, targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new pesticides, herbicides, and fungicides, leveraging its reactive site for creating bioactive molecules.
• Organic Synthesis Reagent: Serves as a versatile acylating agent in academic and industrial laboratories for introducing the 4-oxo-benzoxazine carbonyl moiety into target molecules.
• Material Science Research: Employed in the development of advanced polymers and functional materials, where the benzoxazine structure can impart thermal stability and specific chemical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme activity and biological pathways.

Basic Information

Product Name	4H-3,1-Benzoxazine-2-Carbonyl Chloride, 4-Oxo- (9Ci)
CAS No.	344413-46-3
Molecular Formula	C9H4ClNO3
Molecular Weight	209.59 g/mol
Synonyms	4-Oxo-4H-3,1-benzoxazine-2-carbonyl chloride; 4H-3,1-Benzoxazine-2-carbonyl chloride, 4-oxo-; 2-(Chlorocarbonyl)-4H-3,1-benzoxazin-4-one; 4-Oxo-4H-benzo[d][1,3]oxazine-2-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 4H-3,1-Benzoxazine-2-Carbonyl Chloride, 4-Oxo- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to verify identity and quantify purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP-compliant manufacturing for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.