Description

1-Methyl-1H-Imidazole-5-Carbonyl Chloride Hydrochloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its core value lies in its dual functionality as an acyl chloride and an imidazole derivative, enabling efficient derivatization and heterocyclic chemistry. This compound is primarily needed by pharmaceutical, agrochemical, and specialty chemical R&D teams for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly those containing imidazole or amide moieties.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides requiring specific heterocyclic structures.
• Peptide Coupling Reagent: Acts as an efficient activating agent for amide bond formation in peptide and protein chemistry.
• Material Science Research: Precursor for creating functional polymers, ligands for catalysis, and advanced organic materials.
• Chemical Derivatization: Employed to introduce the 1-methylimidazole-5-carbonyl group into target molecules for property modification.
• Academic & Industrial R&D: Serves as a critical reagent in research laboratories for methodological development and exploratory synthesis.

Basic Information

Product Name	1-Methyl-1H-Imidazole-5-Carbonyl Chloride Hydrochloride
CAS No.	343569-06-2
Molecular Formula	C6H6Cl2N2O
Molecular Weight	193.03 g/mol
Synonyms	1-Methyl-1H-imidazole-5-carbonyl chloride hydrochloride; 1-Methylimidazole-5-carbonyl chloride HCl; 5-(Chlorocarbonyl)-1-methyl-1H-imidazole hydrochloride; 1-Methyl-5-imidazolecarbonyl chloride hydrochloride; 1-Methyl-1H-imidazole-5-carboxylic acid chloride hydrochloride; 1-Methyl-5-imidazolecarboxylic acid chloride hydrochloride; 1-Methylimidazole-5-carboxylic acid chloride hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Methyl-1H-Imidazole-5-Carbonyl Chloride Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high standards, including cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.