Description

1H-Benzimidazole-1-Carbonylchloride(9Ci) CAS NO 343330-46-1 is a highly reactive benzimidazole derivative, serving as a crucial acylating agent and versatile synthetic building block in advanced organic chemistry. Its primary value lies in enabling the efficient introduction of the benzimidazole-carbonyl moiety, a key structural feature in numerous high-value compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel benzimidazole-based drug candidates, including kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the production of advanced fungicides and herbicides that leverage the benzimidazole scaffold for enhanced biological activity.
• Material Science Research: Employed in the development of organic semiconductors, ligands for catalysis, and specialty polymers.
• Peptide & Protein Modification: Acts as a coupling reagent or protecting group strategy in peptide synthesis and bioconjugation chemistry.
• Chemical Biology Probes: Utilized to create activity-based probes and labeling reagents for studying enzyme function and cellular processes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	1H-Benzimidazole-1-Carbonylchloride(9Ci)
CAS No.	343330-46-1
Molecular Formula	C8H5ClN2O
Molecular Weight	180.59 g/mol
Synonyms	1H-Benzimidazole-1-carbonyl chloride; 1-Carboxybenzimidazole Chloride; 1-Benzimidazolecarbonyl Chloride; 1H-Benzimidazol-1-ylcarbonyl Chloride; 1-(Chlorocarbonyl)-1H-benzimidazole; Benzimidazole-1-carbonyl Chloride; 1-Carbobenzimidazole Chloride; NSC 405124
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole-1-Carbonylchloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data with each shipment. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and are standard for all commercial orders.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and should be stored under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Handle and store away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.