Description

2-Pyrrolidinecarbonyl Chloride, 1-(Methylsulfonyl)- (9Ci) is a high-value, reactive sulfonyl pyrrolidine derivative used as a key synthetic intermediate. Its primary commercial value lies in its role as a versatile building block for constructing complex nitrogen-containing heterocycles and pharmacologically active molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced material sectors seeking to introduce specific sulfonamide and cyclic amide functionalities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly protease inhibitors, kinase inhibitors, and other small molecule therapeutics targeting various disease pathways.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the sulfonyl pyrrolidine moiety can enhance biological activity and selectivity.
• Chemical Biology & Proteomics: Serves as a reactive handle for activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors or probes.
• Material Science Research: Employed in the creation of functionalized polymers, ligands for catalysis, and specialty chemicals with tailored properties.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	2-Pyrrolidinecarbonyl Chloride, 1-(Methylsulfonyl)- (9Ci)
CAS No.	343272-41-3
Molecular Formula	C6H10ClNO3S
Molecular Weight	211.67 g/mol
Synonyms	1-(Methylsulfonyl)pyrrolidine-2-carbonyl chloride; N-(Methylsulfonyl)-2-pyrrolidinecarbonyl chloride; 1-Methanesulfonyl-pyrrolidine-2-carboxylic acid chloride; 2-Pyrrolidinecarbonyl chloride, 1-(methylsulfonyl)-; NSC 339241; 1-(Methylsulfonyl)-2-pyrrolidinecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Our production of 2-Pyrrolidinecarbonyl Chloride, 1-(Methylsulfonyl)- (9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.