Description

1H-Indole-3-Carbonyl Chloride,2-Phenyl- is a high-value, reactive chemical intermediate primarily used in advanced organic synthesis. This compound is critical for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is essential for research and production teams in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable source of high-purity building blocks.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those with indole-based scaffolds targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the 2-phenylindole moiety can contribute to biological activity.
• Material Science Research: Serves as a precursor for organic electronic materials, such as charge-transport layers or light-emitting components in OLED research.
• Peptide Mimetics & Bioconjugation: The reactive acid chloride group enables efficient coupling reactions for creating peptide analogs or labeling biomolecules.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.
• Dye & Pigment Intermediate: Potential use in synthesizing specialized indole-based dyes and colorants.

Basic Information

Product Name	1H-Indole-3-Carbonyl Chloride,2-Phenyl-
CAS No.	342404-04-0
Molecular Formula	C15H10ClNO
Molecular Weight	255.70 g/mol
Synonyms	2-Phenyl-1H-indole-3-carbonyl chloride; 2-Phenylindole-3-carbonyl chloride; 1H-Indole-3-carbonyl chloride, 2-phenyl-; 2-Phenyl-1H-indole-3-carboxylic acid chloride; (2-Phenyl-1H-indol-3-yl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1H-Indole-3-Carbonyl Chloride,2-Phenyl- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation by FT-IR and NMR, and impurity profiling. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.