Description

2-Fluoro-5-Nitrophenylisothiocyanate is a specialized aromatic isothiocyanate derivative, distinguished by its reactive isothiocyanate (-N=C=S) group and electron-withdrawing nitro and fluoro substituents. This compound is a critical building block in organic synthesis, particularly valued for its role as a versatile electrophile in the formation of thiourea linkages. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and advanced materials. Its unique structure facilitates the creation of complex molecular architectures with potential biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, especially those targeting specific enzymes or receptors where the thiourea moiety is a critical pharmacophore.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides, leveraging its reactive site to create compounds with specific modes of action.
• Bioconjugation & Labeling Reagent: Employed for modifying proteins, peptides, and other biomolecules by reacting with primary amine groups to form stable thiourea bonds for labeling or immobilization.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, resins, and advanced functional materials.
• Chemical Biology Probe Synthesis: Utilized to create activity-based probes for studying enzyme function and protein interactions within biological systems.
• Ligand Synthesis for Catalysis: Acts as a starting material for synthesizing novel ligands used in transition metal catalysis for asymmetric synthesis.

Basic Information

Product Name	2-Fluoro-5-Nitrophenylisothiocyanate
CAS No.	340719-39-3
Molecular Formula	C7H3FN2O2S
Molecular Weight	198.17 g/mol
Synonyms	1-Fluoro-2-isothiocyanato-4-nitrobenzene; 2-Fluoro-5-nitrobenzenisothiocyanate; 2-Fluoro-5-nitro-phenyl isothiocyanate; 5-Nitro-2-fluorophenyl isothiocyanate; (2-Fluoro-5-nitrophenyl)isothiocyanate; Isothiocyanic acid, 2-fluoro-5-nitrophenyl ester; NSC 405124
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Nitrophenylisothiocyanate is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and loss on drying for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles for production, ensuring suitability for research and development applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.