Description

Zd 6474 Trifluoroacetate is a high-purity, small molecule compound of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate and reference standard in the synthesis of targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology and advanced drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Reference Standard: Used for analytical method development, validation, and quality control in API (Active Pharmaceutical Ingredient) manufacturing.
• Biochemical Research: A tool compound for studying cellular signaling pathways, particularly those involving VEGFR2 (KDR) and EGFR tyrosine kinases.
• Preclinical Development: Employed in the research and early-stage development of anti-angiogenic and anti-tumor agents.
• Chemical Synthesis: Serves as a versatile precursor for further chemical modifications in medicinal chemistry programs.

Basic Information

Product Name	Zd 6474 Trifluoroacetate
CAS No.	338992-53-3
Molecular Formula	C22H24F3N4O3 • C2HF3O2
Molecular Weight	593.55 g/mol
Synonyms	Vandetanib Trifluoroacetate; ZD-6474 Trifluoroacetate; Zactima Trifluoroacetate; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine Trifluoroacetate; AZD-6474 Trifluoroacetate; Vandetanib (ZD6474) Trifluoroacetate Salt; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline Trifluoroacetate
EINECS	Contact for details

Quality Control

Our Zd 6474 Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.