Description

Vandetanib is a small molecule kinase inhibitor targeting specific tyrosine kinases involved in tumor growth and angiogenesis. This compound is of significant commercial and research interest for its targeted therapeutic action. It is primarily utilized in the pharmaceutical industry for the development and production of oncology treatments, as well as in advanced biochemical research for studying signal transduction pathways.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of targeted cancer therapies.
• Reference standard for analytical method development and validation in quality control laboratories.
• Biochemical research tool for studying the inhibition of VEGFR, EGFR, and RET kinases.
• Key intermediate in advanced pharmaceutical synthesis and process development.
• Material for preclinical and clinical research studies in oncology.

Basic Information

Product Name	Vandetanib
CAS No.	338992-00-0
Molecular Formula	C22H24BrF2N4O3
Molecular Weight	510.35 g/mol
Synonyms	ZD6474; Zactima; Vandetanib free base; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; 4-(4-Bromo-2-fluorophenylamino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; AZD6474
EINECS	Contact for details

Quality Control

Our Vandetanib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results for assay, related substances, residual solvents, and other critical parameters, ensuring compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.