Description

3-Thiophenecarbonyl Chloride, 2-Chloro- (9Ci) is a high-purity, reactive organosulfur building block, specifically a functionalized acid chloride derivative. This compound is critical for introducing the 2-chlorothiophene-3-carbonyl moiety into target molecules, enabling precise structural modifications in advanced synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex heterocyclic scaffolds found in potential drug candidates, particularly in kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that incorporate thiophene rings for enhanced bioactivity.
• Material Science Research: Serves as a precursor for functionalized monomers or ligands in the synthesis of conductive polymers, coordination complexes, and advanced organic materials.
• Chemical Biology & Proteomics: Employed as a coupling agent or labeling reagent for modifying biomolecules or creating activity-based probes for target identification.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	3-Thiophenecarbonyl Chloride, 2-Chloro- (9Ci)
CAS No.	332370-74-8
Molecular Formula	C5H2Cl2OS
Molecular Weight	180.04 g/mol
Synonyms	2-Chlorothiophene-3-carbonyl chloride; 2-Chloro-3-thenoyl chloride; 2-Chloro-3-thiophenecarboxylic acid chloride; 3-Thenoyl chloride, 2-chloro-; 2-Chloro-3-thienoyl chloride; 2-Chloro-3-thiophenecarbonyl chloride; 2-Chloro-3-carboxythiophene chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Thiophenecarbonyl Chloride, 2-Chloro- (9Ci) is manufactured and tested under strict quality management protocols. We ensure high chemical purity and lot-to-lot consistency suitable for demanding research and scale-up applications. Comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, is performed. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with water; ensure containers are kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.