Description

8-Bromoguanosine Dihydrate, 97% is a halogenated nucleoside derivative of guanosine, serving as a crucial building block in organic synthesis and biochemical research. This compound is valued for its role in modifying nucleic acid structures and probing enzymatic mechanisms. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for developing novel therapeutics and conducting advanced molecular studies.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in studies of nucleoside-metabolizing enzymes like kinases and phosphorylases.
• Oligonucleotide Synthesis: Serves as a modified monomer for introducing bromine labels or creating structurally altered DNA/RNA strands for structure-activity relationship (SAR) studies.
• Proteomics & Genomics: Employed in cross-linking experiments and as a tool compound for investigating nucleic acid-protein interactions.
• Chemical Biology Probes: Foundation for developing photoaffinity labels or activity-based probes to study cellular processes.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and molecular biology.

Basic Information

Product Name	8-Bromoguanosine Dihydrate, 97%
CAS No.	332359-99-6
Molecular Formula	C10H12BrN5O5 · 2H2O
Molecular Weight	380.16 g/mol (Anhydrous Basis: 344.14 g/mol)
Synonyms	8-Bromo-guanosine Dihydrate; 8-Br-Guanosine Dihydrate; Guanosine, 8-bromo-, dihydrate; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-bromo-3H-purin-6-one dihydrate; 8-Bromoguanosine 2-Hydrate; 8-Bromo-9-β-D-ribofuranosylguanine Dihydrate
EINECS	Contact for details

Quality Control

Our 8-Bromoguanosine Dihydrate, 97% is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house quality standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	8.0 - 11.0 %
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.5 %
Related Substances (HPLC)	Total impurities < 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.